Hello and welcome to this blog. This site was put together using notes I made when preparing for the UK Royal College of Pathology exams. I found them useful and I hope you do too. HLA testing for disease associations is almost as old as the field of HLA research. Early on, there was perhaps a belief that the HLA associations for most common autoimmune diseases would eventually be determined and a nice neat explanation of the basis of these diseases would be established. We now know of course that the situation is that little bit more complicated. The associations are not all 100% and having a predisposing HLA type does not imply that a person would develop the disease in question. Many autoimmune diseases have a polygenic basis with HLA and non HLA genes contributing to disease susceptibility. The advent of genome wide association studies has opened up new avenues for the exploration.
Here at http://www.hladiseaseassociations.com/ I discuss a number of autoimmune and other inflammatory diseases, reviewing the prevalence and epidemiology where known and assessing the value to genetic testing for these conditions. Please sign up for email updates and leave a comment on some of our entries. Lets see if we can get a conversation going.
- Actinic Prurigo
- Addison’s Disease
- Ankylosing Spondylitis
- Behcet’s
- Birdshot Chorioretinopathy
- Coeliac Disease
- Colitis
- Crohn’s
- Drug Hypersensitivity
- Graves Disease
- Haemochromatosis
- Immunosuppressive Drug Metabolism
- HIV Infection
- Insulin Dependent Diabetes Mellitus
- Juvenile Idiopathic Arthritis
- Multiple Sclerosis
- Myasthenia Gravis
- Narcolepsy
- Osteoarthritis
- Polyarthralgia
- Polyarthritis
- Psoriasis Vulgaris
- Reactive Arthritis
- Rheumatoid Arthritis
- Scleroderma
- Sjogrens
- Systemic Lupus Erythematosus
- Uveitis
Ps. Get a copy of the eBook.
- You get all the content of this website in one easy to read pdf format
- You get a list of over 300 references in H&I
- You have access to all the articles even when offline
- You can print at your leisure
- You get pull out tables summarising disease associations
- Finally you will be making a valuable contribution to the upkeep of this site.
Download a free copy of the eBook
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